MCI-225 enhances noradrenergic function by modulating second messenger system in the rat brain

The emotive brain, the noradrenergic system, and cognition

Motivation and attention can have a profound influence on perception, learning and memory. Neuromodulatory systems, especially the noradrenergic (NE) system, co-vary with psychological states to modulate cortical arousal, influence sensory processing and promote synaptic plasticity. There is even some suggestion that the NE system might facilitate functional recovery after brain damage. Post-sy...

The emotive brain, the noradrenergic system, and cognition

Motivation and attention can have a profound influence on perception, learning and memory. Neuromodulatory systems, especially the noradrenergic (NE) system, co-vary with psychological states to modulate cortical arousal, influence sensory processing and promote synaptic plasticity. There is even some suggestion that the NE system might facilitate functional recovery after brain damage. Post-sy...

The effect of lithium on the adrenoceptor-mediated second messenger system in the rat brain.

OBJECTIVE Lithium remains the most widely used treatment for bipolar disorder; however, the molecular mechanisms underlying its therapeutic actions have not been fully elucidated. We studied the in-vivo effect of lithium on the density of alpha-adrenoceptor (alpha-AR) and beta-AR subtypes and linked second messenger systems in the rat brain. METHODS The densities of alpha(1)-ARs, alpha(2)-ARs...

Postnatal changes in the noradrenergic system modulating hypoglossal motoneurons

The Second Messenger System Involving Adenyl Cyclase

Cyclic AMP (adenosine 3',5'-monophosphate or cyclic adenylate) has now been established as a second messenger mediating many of the effects of a variety of hormones. Severial of the metabolic effects mediated by cyclic AMP are discussed, and it is suggested that certain other ("functional" or "mechanical") hormonal effects may be similarly mediated. In particular, the evidence presented support...